Isabella Silva-Barreto, Lund University

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Isabella Silva-Barreto from Lund University will give a seminar entitled "Synchrotron-based characterization of mechanobiological effects on the nanoscale in musculoskeletal tissues" on Friday, April 28, 2023 at 10:00 a.m. in the Espace photonique meeting room.

Abstract : Both mineralized and soft collagenous tissues respond to their mechanical loading environment according to specific mechanobiological principles. During prenatal development, immobilization can cause dramatic effects on the developing skeleton, causing the newly formed bones to be smaller, deformed and more prone to fracture. But how immobilization affects the deposition, structure and composition of the developing bones is still unclear. In tendons, both insufficient and excessive mechanical loading increases the risk of injury. After rupture, reduced mechanical loading has resulted in altered collagen structure and cell activity, thus influencing the mechanical properties of the healing tendon as well as the risk for re-rupture. There is however limited knowledge on how the loading environment affects the structure of intact and ruptured tendon, and there is still no consensus on optimal rehabilitation protocols.
This talk will present the characterization of the mechanobiological effects on the mineralization process in developing bones as well as the collagen structure and mechanical response of intact and healing tendons. This is achieved through a multimodal approach utilizing high-resolution synchrotron-based techniques (small- and wide-angle X-ray scattering, small angle X-ray tensor tomography and X-ray fluorescence) and conventional lab-based techniques (Fourier-transform infrared spectroscopy and polarized light microscopy) in combination with in situ mechanical testing.

Invitation : Tilman Grunewald