Pushing the Frontiers of Single-Molecule Fluorescence Detection with Nanophotonics
Principal Investigator: Jerome Wenger
Our aim is to advance single-molecule detection beyond the traditional limits imposed by optical diffraction. By integrating nanophotonic components into advanced microscopes, we enhance the fluorescence brightness of single molecules and extend their domain of detection. Our ultimate goal is to watch molecules better, faster and with higher spatio-temporal resolutions.
We use nanophotonic structures (zero-mode waveguide nanoapertures, horn antennas, plasmonic nanogap antennas) to confine light in nanoscale dimensions and enhance the fluorescence emission from target molecules. These nanostructures are combined with cutting-edge time-resolved fluorescence spectroscopy techniques (FCS, TCSPC, FRET) to probe single molecules with unprecedented sensitivity.
At the interfaces between nanophotonics and biophotonics, our research advances the fundamental understanding of nanoscale light-matter interaction and contributes to the development of innovative spectroscopy techniques.
Recent work and updates from Jerome Wenger’s group
More info on Jerome Wenger’s research
Funding
