Mosaic is an interdisciplinary research group aiming at unravelling life science problems using advanced photonic tools.
Mosaic principal investigators are physicists and biologists working together at the cross roads between advanced optical imaging, nanophotonics and tissue morphogenesis.
The Mosaic group is involved in collaborative projects related to the fields of developmental biology, immunology, neurosciences and biomedical research.
Optical microscopy techniques developped by the Mosaic group:
– Fluorescence correlation spectroscopy (FCS)
– Fluorescence lifetime spectroscopy (FLIM)
– Polarization resolved 1 and 2-photon confocal microscopy
– Polarization resolved superresolution microscopy (STORM)
– Quantitative phase imaging (QPI)
– Coherent Raman (CARS / SRS/ CSRS) microscopy, spectroscopy
– 2-Photon, SHG, THG microscopy
– Nonlinear endoscopy (2-Photon, SHG, THG, CARS, SRS)
Biological problems addressed by Mosaic
– The interplay between the dynamic organization of cytoskeletal filaments and cell shape changes
– The reciprocal links between tissue growth, morphogenesis and tissue mechanics
Infrastructure :
– 10 optical Labs
– 1 chemistry Lab
– 1 mammalian cell culture Lab (L2)
– 1 Drosophila Lab
– 1 animal (mice) Lab
– 1 biology Lab (bacteria L1)
On-Line Application
Virtual Histology coloring App: Massilia-VH is an open-access on-line application that generates histology (H&E) images from SRS CH2 and CH3 images
Massilia Virtual Histology (Massilia-VH)
