For spectroscopy and imaging
Principal investigator : Hervé Rigneault
Keywords : micro-structured optical fibers, ultra-thin endoscope, wavefront shaping, nonlinear imaging
We are interested in extending molecular spectroscopy and nonlinear imaging through flexible fiber probes and endoscopes. Using specially design micro-structured fibers, we are investigating
(1) the use of hollow core photonic crystal fibers for flexible nonlinear imaging endoscopes and Raman probes.
(2) the use of multicore fibers combined with wavefront shaping for ultra-thin nonlinear imaging endoscope.
Hollow core photonic crystal fiber for flexible nonlinear imaging endoscopes and Raman probes.
Delivering ultra-short laser pulses through fiber optics is limited by the nonlinear interactions (self-phase modulation, Four-Wave Mixing , stimulated Raman) in the silica fiber core that affect the pulse spectral and time profiles. Here we are using specially designed hollow core fibers to deliver ultra-short pulses at the fiber distal end, taking advantage of the ultra-low nonlinearity of the air core and the small dispersion of this type of fiber. In these fibers a short pulse (50fs – 1ps) coupled inside the fiber remains the same at the fiber output making them ideal for ultra)short pulse delivery at the endoscope distal end. We build these fibers wit a double silica clad for optimal nonlinear signal (2photon, 3photon, SHG, THG, CARS) signal back collection.
Ultra-thin endoscope using multicore fibers
We are combining wavefront shaping with multicore fibers to perform distal beam scanning imaging without the use of any distal optics. This is possible by controlling the phase of the light that is injected in every cores of the multicore fiber. When properly phased, the interference of the light coming from each fiber core creates a focus spot that can be scanned accross the sample plane. The nonlinear signal (2photon, SHG) is collected by the multicore fiber double clad. This ultra-thin endoscope has a diameter that reduces to the size of the fiber itself (150µm – 250µm).
Nonlinear flexible endoscopes are used to address :
– Deep brain imaging and neuron network activity in living mice (neurobiology) (
– Deep tissue morphology (tissues, skin, plants…)
The fibers used are developped in collaboration with the PhLAM laboratory in Lille (FR), the University of Bath (UK), and the University of Erlangen (DE).
Publications
2025
A two-photon lensless endoscope with a double-clad tapered multi-core fiber
L. Genchi, M. Hofer, A. Carron, F. El Moussawi, A. Pastre, R. Bernard, D. Labat, A. Cassez, R. Cossart, O. Vanvincq, G. Bouwmans, S. Sivankutty, H. Rigneault, and E. Ravn Andresen, , Opt. Lett. 50, 2626-2629 (2025); 10.1364/OL.550709
2024
Interferometric Lensless Imaging: Rank-One Projections of Image Frequencies with Speckle Illuminations
O. Leblanc, M. Hofer, S. Sivankutty, H. Rigneault, and L. Jacques, “,” IEEE Transactions on Computational Imaging, 1-15 (2024), 10.1109/TCI.2024.3359178
A hollow-core fiber based stand-alone multimodal (2-photon, 3-photon, SHG, THG) nonlinear flexible imaging endoscope system2024
D. Septier, G. Brévalle-Wasilewski, E. Lefebvre, N. G. Kumar, Y. J. Wang, A. Kaszas, H. Rigneault, and A. Kudlinski, IEEE Journal of Selected Topics in Quantum Electronics, 1-13 (2024); 10.1109/JSTQE.2024.3411821
2023
Hollow Core Double-Clad Fiber Coupler for Nonlinear Micro-Endoscopy
Septier, D. Labat, A. Pastre, R. Bernard, G. Brévalle-Wasilewski, H. Rigneault, G. Bouwmans, and A. Kudlinski, “,” Journal of Lightwave Technology 41, 4792-4798 (2023); 10.1109/JLT.2023.324287
Coupling optimized bending-insensitive multi-core fibers for lensless endoscopy
N. Gajendra Kumar, S. Sivankutty, V. Tsvirkun, A. Cassez, D. Labat, R. Cossart, G. Bouwmans, E. R. Andresen, and H. Rigneault
Optics Express 31, 15334-15341 (2023); doi.org/10.1364/OE.485550
Sub-diffraction computational imaging via a flexible multicore-multimode fiber
Z. Lyu, K. Abrashitova, J. F. de Boer, E. R. Andresen, H. Rigneault, and L. V. Amitonova
Optics Express 31, 11249-11260 (2023); opg.optica.org/oe/abstract.cfm ?uri=oe-31-7-11249
2022
Tapered Multicore Fiber for Lensless Endoscopes
F. El Moussawi, M. Hofer, D. Labat, A. Cassez, G. Bouwmans, S. Sivankutty, R. Cossart, O. Vanvincq, H. Rigneault, and E. R. Andresen
ACS Photonics 30, 25020 (2022); https://doi.org/10.1021/acsphotonics.2c00661
Label-free highly multimodal nonlinear endoscope
D. Septier, V. Mytskaniuk, R. Habert, D. Labat, K. Baudelle, A. Cassez, G. Brévalle-Wasilewski, M. Conforti, G. Bouwmans, H. Rigneault, and A. Kudlinski
Optics Express 30, 25020-25033 (2022); https://doi.org/10.1364/OE.462361
Compressive Imaging Through Optical Fiber with Partial Speckle Scanning
S. Guérit, S. Sivankutty, J. Lee, H. Rigneault, and L. Jacques,
SIAM Journal on Imaging Sciences 15, 387-423 (2022); doi.org/10.1137/21M1407586
2021
Miniature 120-beam coherent combiner with 3D-printed optics for multicore fiber-based endoscopy
S. Sivankutty, A. Bertoncini, V. Tsvirkun, N. Gajendra Kumar, G. Brévalle, G. Bouwmans, E. R. Andresen, C. Liberale, and H. Rigneault
Optics Letters 46, 4968-4971 (2021); doi.org/10.1364/OL.435063
2020
Double clad tubular anti-resonant hollow core fiber for nonlinear microendoscopy
A. Kudlinski, A. Cassez, O. Vanvincq, D. Septier, A. Pastre, R. Habert, K. Baudelle, M. Douay, V. Mytskaniuk, V. Tsvirkun, H. Rigneault, and G. Bouwmans
Optics Express 28, 15062-15070 (2020); doi.org/10.1364/OE.389084
2019
Flexible lensless endoscope with a conformationally invariant multi-core fiber
V. Tsvirkun, S. Sivankutty, K. Baudelle, R. Habert, G. Bouwmans, O. Vanvincq, E. R. Andresen, and H. Rigneault
Optica 6, 1185-1189 (2019); 10.1364/OPTICA.6.001185
2018
Single-shot noninterferometric measurement of the phase transmission matrix in multicore fibers
S. Sivankutty, V. Tsvirkun, G. Bouwmans, E. R. Andresen, D. Oron, H. Rigneault, and M. A. Alonso
Optics Letters 43, 4493-4496 (2018); 10.1364/OL.43.004493
Nonlinear imaging through a Fermat’s golden spiral multicore fiber
S. Sivankutty, V. Tsvirkun, O. Vanvincq, G. Bouwmans, E. R. Andresen, and H. Rigneault
Optics Letters 43, 3638-3641 (2018); 10.1364/OL.43.003638
High-resolution multimodal flexible coherent Raman endoscope
Lombardini, V. Mytskaniuk, S. Sivankutty, E. R. Andresen, X. Chen, J. Wenger, M. Fabert, N. Joly, F. Louradour, A. Kudlinski, and H. Rigneault, Light: Science & Applications 7, 10 (2018), 10.1038/s41377-018-0003-3
2017
Bending-induced inter-core group delays in multicore fibers
V. Tsvirkun, S. Sivankutty, G. Bouwmans, O. Vanvincq, E. R. Andresen, and H. Rigneault
Optics Express 25, 31863-31875 (2017); 10.1364/OE.27.031290
Origin and suppression of parasitic signals in Kagomé lattice hollow core fibers used for SRS microscopy and endoscopy
A. Lombardini, E. R. Andresen, A. Kudlinski, I. Rimke, and H. Rigneault
Optics Letters 42, 1824-1827 (2017)
Phase retrieval in multi-core fiber bundles
D. Kogan, S. Sivankutty, V. Tsirkun, G. Bouwmans, E. R. Andresen, H. Rigneault, D. Oron
Optics Letters 42, 647-650 (2017)
2016
Widefield lensless endoscopy with a multicore fiber
V. Tsvirkun, S. Sivankutty, G. Bouwmans, O. Katz, E. R. Andresen, and H. Rigneault
Optics Letters 41, 4771 (2016)
Ultrathin endoscopes based on multicore fibers and adaptive optics : a status review and perspectives
Esben Ravn Andresen, Siddharth Sivankutty, Viktor Tsvirkun, Géraud Bouwmans, Hervé Rigneault
J. Biomedical Optics 21, 121506 (2016)
Extended field-of-view in a lensless endoscope using an aperiodic multicore fiber
S. Sivankutty, V. Tsvirkun, G. Bouwmans, D. Kogan, D. Oron, E. R. Andresen, and H. Rigneault
Optics Letters 41, 3531-3534 (2016)
Widefield lensless imaging through a fiber bundle via speckle correlations
A. Porat, E. R. Andresen, H. Rigneault, D. Oron, S. Gigan, and O. Katz
Optics Express 24, 16835-16855 (2016)
Single-shot polarimetry imaging of multicore fiber
S. Sivankutty, E. R. Andresen, G. Bouwmans, T. G. Brown, M. A. Alonso, H. Rigneault
Optics Letters 41, 2105-2108 (2016)
Ultra-thin rigid endoscope : two-photon imaging through a graded-index multi-mode fiber
S. Sivankutty, E. R. Andresen, R. Cossart, G. Bouwmans, S. Monneret, H. Rigneault
Optics Express 24, 825 (2016)
2015
Measurement and compensation of residual group delay in a multi-core fiber for lensless endoscopy
E. R. Andresen, S. Sivankutty, G. Bouwmans, L. Gallais, S. Monneret, and H. Rigneault
J. Opt. Soc. Am. B 32, 1221-1228 (2015)
2013
Two-photon lensless endoscope
E. Andresen, G. Bouwmans, S. Monneret, H. Rigneault
Optics Express 21, 20713-20721 (2013)
Toward endoscopes with no distal optics : video-rate scanning microscopy through a fiber bundle
E. R. Andresen, G. Bouwmans, S. Monneret, and H. Rigneault
Optics Letters 38, 609-611 (2013)
2012
Hollow-core photonic crystal fiber probe for remote fluorescence sensing with single molecule sensitivity
P. Ghenuche, H. Rigneault and J. Wenger
Optics Express 20, 28370-28387 (2012)
Kagome hollow-core photonic crystal fiber probe for Raman spectroscopy
P. Ghenuche, S. Rammler, N. Y. Joly, M. Scharrer, M. Frosz, J. Wenger, P. St. J. Russell, and H. Rigneault
Optics Letters 37, 4371–4373 (2012)
2011
Double-clad hollow core photonic crystal fiber for coherent Raman endoscope
S. Brustlein, P. Berto, R. Hostein, P. Ferrand, C. Billaudeau, D. Marguet, A. Muir, J. Knight, H. Rigneault
Optics Express 19, 12562 – 12568 (2011)
Fundings:
