For biosensing and imaging
Principal investigator : Hervé Rigneault
Keywords : nonlinear endoscope, lensless endoscope, wavefront shaping, micro-structured optical fibers, Raman probes
We are interested in extending molecular spectroscopy and nonlinear imaging through flexible fiber probes and endoscopes. Using specially design micro-structured fibers, we are investigating
(1) the use of hollow core photonic crystal fibers for flexible nonlinear imaging endoscopes and Raman probes.
(2)the use of multicore and multimode fibers combined with wavefront shaping for lensless nonlinear imaging endoscope.
Hollow core photonic crystal fiber for flexible nonlinear imaging endoscopes and Raman probes.
Delivering ultra-short laser pulses through fiber optics is limited by the nonlinear interactions (SPM, FWM, Raman) in the silica fiber core that affect the pulse spectral and time profiles. Here we are using specially designed band gap and Kagome lattice hollow core fibers to deliver ultra-short pulses at the fiber distal end, taking advantage of the ultra-low nonlinearity of the air core. These fibers also feature a double silica clad for optimal nonlinear and Raman signal back collection.
Lensless endoscope
We are combining wavefront shaping with multicore or multimode fibers to perform distal beam scanning imaging without the use of any distal optics. This produce imaging endoscope with diameters as small as few hundreds of microns fully compatible with nonlinear imaging.
Nonlinear flexible endoscopes and distal Raman probes are used to address :
– Deep brain imaging and neuron network activity in living mice (neurobiology)
– Deep tissue morphology
– Deep tissue Raman spectroscopy
Publications
2023
Coupling optimized bending-insensitive multi-core fibers for lensless endoscopy
N. Gajendra Kumar, S. Sivankutty, V. Tsvirkun, A. Cassez, D. Labat, R. Cossart, G. Bouwmans, E. R. Andresen, and H. Rigneault
Optics Express 31, 15334-15341 (2023).
doi.org/10.1364/OE.485550
Sub-diffraction computational imaging via a flexible multicore-multimode fiber
Z. Lyu, K. Abrashitova, J. F. de Boer, E. R. Andresen, H. Rigneault, and L. V. Amitonova
Optics Express 31, 11249-11260 (2023)
opg.optica.org/oe/abstract.cfm ?uri=oe-31-7-11249
2022
Tapered Multicore Fiber for Lensless Endoscopes
F. El Moussawi, M. Hofer, D. Labat, A. Cassez, G. Bouwmans, S. Sivankutty, R. Cossart, O. Vanvincq, H. Rigneault, and E. R. Andresen
ACS Photonics 30, 25020 (2022)
https://doi.org/10.1021/acsphotonics.2c00661
Label-free highly multimodal nonlinear endoscope
D. Septier, V. Mytskaniuk, R. Habert, D. Labat, K. Baudelle, A. Cassez, G. Brévalle-Wasilewski, M. Conforti, G. Bouwmans, H. Rigneault, and A. Kudlinski
Optics Express 30, 25020-25033 (2022)
https://doi.org/10.1364/OE.462361
Compressive Imaging Through Optical Fiber with Partial Speckle Scanning
S. Guérit, S. Sivankutty, J. Lee, H. Rigneault, and L. Jacques,
SIAM Journal on Imaging Sciences 15, 387-423 (2022)
doi.org/10.1137/21M1407586
2021
Miniature 120-beam coherent combiner with 3D-printed optics for multicore fiber-based endoscopy
S. Sivankutty, A. Bertoncini, V. Tsvirkun, N. Gajendra Kumar, G. Brévalle, G. Bouwmans, E. R. Andresen, C. Liberale, and H. Rigneault
Optics Letters 46, 4968-4971 (2021)
doi.org/10.1364/OL.435063
2020
Double clad tubular anti-resonant hollow core fiber for nonlinear microendoscopy
A. Kudlinski, A. Cassez, O. Vanvincq, D. Septier, A. Pastre, R. Habert, K. Baudelle, M. Douay, V. Mytskaniuk, V. Tsvirkun, H. Rigneault, and G. Bouwmans
Optics Express 28, 15062-15070 (2020)
doi.org/10.1364/OE.389084
2019
Flexible lensless endoscope with a conformationally invariant multi-core fiber
V. Tsvirkun, S. Sivankutty, K. Baudelle, R. Habert, G. Bouwmans, O. Vanvincq, E. R. Andresen, and H. Rigneault
Optica 6, 1185-1189 (2019)
2018
Single-shot noninterferometric measurement of the phase transmission matrix in multicore fibers
S. Sivankutty, V. Tsvirkun, G. Bouwmans, E. R. Andresen, D. Oron, H. Rigneault, and M. A. Alonso
Optics Letters 43, 4493-4496 (2018)
Nonlinear imaging through a Fermat’s golden spiral multicore fiber
S. Sivankutty, V. Tsvirkun, O. Vanvincq, G. Bouwmans, E. R. Andresen, and H. Rigneault
Optics Letters 43, 3638-3641 (2018)
2017
Bending-induced inter-core group delays in multicore fibers
V. Tsvirkun, S. Sivankutty, G. Bouwmans, O. Vanvincq, E. R. Andresen, and H. Rigneault
Optics Express 25, 31863-31875 (2017)
Origin and suppression of parasitic signals in Kagomé lattice hollow core fibers used for SRS microscopy and endoscopy
A. Lombardini, E. R. Andresen, A. Kudlinski, I. Rimke, and H. Rigneault
Optics Letters 42, 1824-1827 (2017)
Phase retrieval in multi-core fiber bundles
D. Kogan, S. Sivankutty, V. Tsirkun, G. Bouwmans, E. R. Andresen, H. Rigneault, D. Oron
Optics Letters 42, 647-650 (2017)
2016
Widefield lensless endoscopy with a multicore fiber
V. Tsvirkun, S. Sivankutty, G. Bouwmans, O. Katz, E. R. Andresen, and H. Rigneault
Optics Letters 41, 4771 (2016)
Ultrathin endoscopes based on multicore fibers and adaptive optics : a status review and perspectives
Esben Ravn Andresen, Siddharth Sivankutty, Viktor Tsvirkun, Géraud Bouwmans, Hervé Rigneault
J. Biomedical Optics 21, 121506 (2016)
Extended field-of-view in a lensless endoscope using an aperiodic multicore fiber
S. Sivankutty, V. Tsvirkun, G. Bouwmans, D. Kogan, D. Oron, E. R. Andresen, and H. Rigneault
Optics Letters 41, 3531-3534 (2016)
Widefield lensless imaging through a fiber bundle via speckle correlations
A. Porat, E. R. Andresen, H. Rigneault, D. Oron, S. Gigan, and O. Katz
Optics Express 24, 16835-16855 (2016)
Single-shot polarimetry imaging of multicore fiber
S. Sivankutty, E. R. Andresen, G. Bouwmans, T. G. Brown, M. A. Alonso, H. Rigneault
Optics Letters 41, 2105-2108 (2016)
Ultra-thin rigid endoscope : two-photon imaging through a graded-index multi-mode fiber
S. Sivankutty, E. R. Andresen, R. Cossart, G. Bouwmans, S. Monneret, H. Rigneault
Optics Express 24, 825 (2016)
2015
Measurement and compensation of residual group delay in a multi-core fiber for lensless endoscopy
E. R. Andresen, S. Sivankutty, G. Bouwmans, L. Gallais, S. Monneret, and H. Rigneault
J. Opt. Soc. Am. B 32, 1221-1228 (2015)
2013
Two-photon lensless endoscope
E. Andresen, G. Bouwmans, S. Monneret, H. Rigneault
Optics Express 21, 20713-20721 (2013)
Toward endoscopes with no distal optics : video-rate scanning microscopy through a fiber bundle
E. R. Andresen, G. Bouwmans, S. Monneret, and H. Rigneault
Optics Letters 38, 609-611 (2013)
2012
Hollow-core photonic crystal fiber probe for remote fluorescence sensing with single molecule sensitivity
P. Ghenuche, H. Rigneault and J. Wenger
Optics Express 20, 28370-28387 (2012)
Kagome hollow-core photonic crystal fiber probe for Raman spectroscopy
P. Ghenuche, S. Rammler, N. Y. Joly, M. Scharrer, M. Frosz, J. Wenger, P. St. J. Russell, and H. Rigneault
Optics Letters 37, 4371–4373 (2012)
2011
Double-clad hollow core photonic crystal fiber for coherent Raman endoscope
S. Brustlein, P. Berto, R. Hostein, P. Ferrand, C. Billaudeau, D. Marguet, A. Muir, J. Knight, H. Rigneault
Optics Express 19, 12562 – 12568 (2011)
