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The (near) field of Pathogens


The 80 project involves two CNRS institutes :
-  INSB with the MDVA1 group from the IRIM2 in Montpellier
-  INSIS with the CONCEPT and RCMO3 groups from the Fresnel Institute in Marseille.

The aim of the CpP project is to demonstrate the contribution of all-dielectric resonant supports [1-6] as support lamellae (called e-substrates) for TIRF microscopy and associated microscopy techniques (PALM, ImFCS ...). This contribution will be tested using controlled molecular models [7] (models of supported lipid bilayers) and cell samples (such as virus production on the membrane surface of cells) [8]. The ultimate goal is to improve, among other things, the signal-to-noise ratio in TIRF microscopy and thus follow the viral budding of HIV at the membrane.

Figure 1

1 Membrane Domains and Viral Assembly
2 Institut de recherche en infectiologie de Montpellier
3 Research in materials, components and optical thin films technologies

PI : Cyril Favard (IRIM) and Aude Lereu (Institut Fresnel)

Le projet CpP - Le Champ (proche) des Pathogènes est l’un des 80 lauréats de l’appel à projet du CNRS 80 lancé fin 2018. Dans le cadre de ses 80 ans, le CNRS a voulu promouvoir l’interdisciplinarité entre instituts du CNRS. Ce projet implique deux instituts du CNRS l’INSB et l’INSIS et à pour but d’approfondir la connaissance des mécanismes du bourgeonnement viral du virus HIV aux membranes, grâce à des développements en microscopie optique, pour ainsi mieux comprendre sa prolifération.

Reference :
[1] A. L. Lereu, F. Lemarchand, M. Zerrad, A. Passian and C. Amra, submitted to OE (2019).
[2] A. L. Lereu, M. Zerrad, A. Passian and C. Amra Appl. Phys. Lett. 111, 011107 (2017).
[3] M. Zerrad, A. L. Lereu, C. Ndiaye, F. Lemarchand, and C. Amra, Opt. Express 25, 14883 (2017).
[4] C. Ndiaye, M. Zerrad, A. L. Lereu, F. Lemarchand, and C. Amra, Appl. Phys. Lett. 103, 131102 (2013).
[5] A. L. Lereu, M. Zerrad, C. Ndiaye, F. Lemarchand, and C. Amra, Appl. Opt. 53, A412-A416 (2014).
[6] C. Ndiaye, F. Lemarchand, M. Zerrad, D. Ausserré, and C. Amra, Appl. Opt. 50, C382-C387 (2011).
[7] N. Yandrapalli, Q. Lubart, HS. Tanwar, C. Picart, J. Mak, D. Muriaux, C. Favard, Sci Rep. 6:39332 (2016).
[8] C. Floderer, JB. Masson, E. Boilley, et al, C. Favard*, D. Muriaux*, Sci Rep. 8:16283 (2018).