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The (near) field of Pathogens

CpP

The 80 project involves two CNRS institutes :
  INSB with the MDVA1 group from the IRIM2 in Montpellier
  INSIS with the CONCEPT and RCMO3 groups from the Fresnel Institute in Marseille.

The aim of the CpP project is to demonstrate the contribution of all-dielectric resonant supports [1-6] as support lamellae (called e-substrates) for TIRF microscopy and associated microscopy techniques (PALM, ImFCS ...). This contribution will be tested using controlled molecular models [7] (models of supported lipid bilayers) and cell samples (such as virus production on the membrane surface of cells) [8]. The ultimate goal is to improve, among other things, the signal-to-noise ratio in TIRF microscopy and thus follow the viral budding of HIV at the membrane.

1 Membrane Domains and Viral Assembly
2 Institut de recherche en infectiologie de Montpellier
3 Research in materials, components and optical thin films technologies

PI : Cyril Favard (IRIM) and Aude Lereu (Institut Fresnel)

Le projet CpP - Le Champ (proche) des Pathogènes est l’un des 80 lauréats de l’appel à projet du CNRS 80 lancé fin 2018. Dans le cadre de ses 80 ans, le CNRS a voulu promouvoir l’interdisciplinarité entre instituts du CNRS. Ce projet implique deux instituts du CNRS l’INSB et l’INSIS et à pour but d’approfondir la connaissance des mécanismes du bourgeonnement viral du virus HIV aux membranes, grâce à des développements en microscopie optique, pour ainsi mieux comprendre sa prolifération.

Reference :
[1] A. L. Lereu, F. Lemarchand, M. Zerrad, A. Passian and C. Amra, submitted to OE (2019).
[2] A. L. Lereu, M. Zerrad, A. Passian and C. Amra Appl. Phys. Lett. 111, 011107 (2017).
[3] M. Zerrad, A. L. Lereu, C. Ndiaye, F. Lemarchand, and C. Amra, Opt. Express 25, 14883 (2017).
[4] C. Ndiaye, M. Zerrad, A. L. Lereu, F. Lemarchand, and C. Amra, Appl. Phys. Lett. 103, 131102 (2013).
[5] A. L. Lereu, M. Zerrad, C. Ndiaye, F. Lemarchand, and C. Amra, Appl. Opt. 53, A412-A416 (2014).
[6] C. Ndiaye, F. Lemarchand, M. Zerrad, D. Ausserré, and C. Amra, Appl. Opt. 50, C382-C387 (2011).
[7] N. Yandrapalli, Q. Lubart, HS. Tanwar, C. Picart, J. Mak, D. Muriaux, C. Favard, Sci Rep. 6:39332 (2016).
[8] C. Floderer, JB. Masson, E. Boilley, et al, C. Favard*, D. Muriaux*, Sci Rep. 8:16283 (2018).