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We offer a technological platform dedicated to provide innovative optical solutions to researchers mostly working in the field of life sciences

Contact: Hervé Rigneault

Available techniques: (Summary sheet here)

o Quantitative phase microscopy (Spec. sheet and images)

o Polarization-resolved microscopy

o Correlation Fluorescence Spectroscopy

o Coherent Raman (CARS / SRS) microscopy

o Nonlinear (2photon, SHG, THG) microscopy

These instruments are coupled to a L2 laboratory for the
manipulation of biological samples and mammalian cell culture.

Examples of application:

Dry mass / Optical retardance / Refractive index or optical thickness distribution
Orientation of C-H bonds in mouse myelin / Actin filaments organization
Mapping drug distribution in pharmaceutical products / Drug penetration in tissues (skin / hair)
Lipid imaging / Metabolic imaging with deuterated molecules
Tissue morphology / architecture / Developmental biology / Cancer tissues
Single molecule fluctuation dynamics / Conformational modulations / FRET analysis
Measurement of hydrodynamic radii of proteins

Regular partners:
Local: Centre d’Immunologie de Marseille Luminy, Institut de Biologie du Développement de Marseille, Institut Paoli Calmette, Institut des Neurosciences de la Timone, Institut de Neurobiologie de la Méditerranée, Centre de Recherche en Cancérologie de Marseille, ...
National: Phasics, L’Oréal, Galderma, Abbelight, IINS Bordeaux, CBS Montpellier, Institut Curie Paris, PhLAM/IRCICA Lille, LNIO Troyes, LKB ENS Paris, ...
International: Weizmann Institute of Science, FOM Institute AMOLF Amsterdam, ICFO Barcelona, ...

This platform belongs to the following national networks: