Equipe : Thématiques

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New fiber probes

for biosensing and imaging

Principal investigator : Hervé Rigneault

keywords : nonlinear endoscope, lensless endoscope, wavefront shaping, micro-structured optical fibers, Raman probes

We are interested in extending molecular spectroscopy and nonlinear imaging through flexible fiber probes and endoscopes. Using specially design micro-structured fibers, we are investigating

  • (1) the use of hollow core photonic crystal fibers for flexible nonlinear imaging endoscopes and Raman probes.
  • (2)the use of multicore and multimode fibers combined with wavefront shaping for lensless nonlinear imaging endoscope.

Hollow core photonic crystal fiber for flexible nonlinear imaging endoscopes and Raman probes.

Delivering ultra-short laser pulses through fiber optics is limited by the nonlinear interactions (SPM, FWM, Raman) in the silica fiber core that affect the pulse spectral and time profiles. Here we are using specially designed band gap and Kagome lattice hollow core fibers to deliver ultra-short pulses at the fiber distal end, taking advantage of the ultra-low nonlinearity of the air core. These fibers also feature a double silica clad for optimal nonlinear and Raman signal back collection.

Lensless endoscope

We are combining wavefront shaping with multicore or multimode fibers to perform distal beam scanning imaging without the use of any distal optics. This produce imaging endoscope with diameters as small as few hundreds of microns fully compatible with nonlinear imaging.

Nonlinear flexible endoscopes and distal Raman probes are used to address :

  • Deep brain imaging and neuron network activity in living mice (neurobiology)
  • Deep tissue morphology
  • Deep tissue Raman spectroscopy

Publications

2016
Single-shot polarimetry imaging of multicore fiber
S. Sivankutty, E. R. Andresen, G. Bouwmans, T. G. Brown, M. A. Alonso, H. Rigneault
Optics Letters 41, 2105-2108 (2016)
Ultra-thin rigid endoscope : two-photon imaging through a graded-index multi-mode fiber
S. Sivankutty, E. R. Andresen, R. Cossart, G. Bouwmans, S. Monneret, H. Rigneault
Opt. Express 24, 825 (2016)
2015
Measurement and compensation of residual group delay in a multi-core fiber for lensless endoscopy
E. R. Andresen, S. Sivankutty, G. Bouwmans, L. Gallais, S. Monneret, and H. Rigneault
J. Opt. Soc. Am. B 32, 1221-1228 (2015)
2013
Two-photon lensless endoscope
E. Andresen, G. Bouwmans, S. Monneret, H. Rigneault
Opt. Express 21, 20713-20721 (2013)
Toward endoscopes with no distal optics : video-rate scanning microscopy through a fiber bundle
E. R. Andresen, G. Bouwmans, S. Monneret, and H. Rigneault
Optics Letters 38, 609-611 (2013)
2012
Hollow-core photonic crystal fiber probe for remote fluorescence sensing with single molecule sensitivity
P. Ghenuche, H. Rigneault and J. Wenger
Opt Express 20, 28370-28387 (2012)
Kagome hollow-core photonic crystal fiber probe for Raman spectroscopy
P. Ghenuche, S. Rammler, N. Y. Joly, M. Scharrer, M. Frosz, J. Wenger, P. St. J. Russell, and H. Rigneault
Optics Letters 37, 4371–4373 (2012)
2011
Double-clad hollow core photonic crystal fiber for coherent Raman endoscope
S. Brustlein, P. Berto, R. Hostein, P. Ferrand, C. Billaudeau, D. Marguet, A. Muir, J. Knight, H. Rigneault
Optics Express 19, 12562 – 12568 (2011)